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This article examines the evidence on tirzepatide and sleep, explores possible contributing factors, and provides practical guidance for managing sleep quality during treatment

Side Effect Overview: GLP-1s, Stimulants & Other Diet Pills GLP-1 receptor agonists such as semaglutide (Wegovy, Ozempic), orforglipron (Foundayo) and liraglutide (Saxenda), and GIP and GLP-1 receptor agonists like tirzepatide (Zepbound, Mounjaro) often cause stomach side effects like diarrhea, upset stomach (nausea or vomiting), heartburn, gas, constipation, or appetite loss, among other side effects

Additionally, they decreased inflammatory markers such as kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), tumor necrosis factor alpha (TNF-), and interleukin-6 (IL-6)

doi:10.1530/JOE-18-0374 291

As stated earlier, the microbiomes found in the digestive system have a significant impact on both the maturation and functioning of the central nervous system